Practically there is a risk of explosion, and different structures' behavior should be examined against the effects of blast loadings. Sandwich panels are used for making some industrial and military structures. These panels are made of two sheets and an intermediate core. The core has a significant role in reducing the deflection and enhancing energy absorb of structure. In this study, sandwich panels' behavior, which are made of aluminum and steel, are examined against the blast loadings. In the process of analysis, three kind of profiles, which are: rectangular, trapezoidal and triangular, are considered as panel cores. The results show that all the panels that are completely made of aluminum have more damped energy than others. Those panels which have only aluminum sheets or aluminum cores are placed next to whole aluminum panels in order to damped energy level. Most of the deflections in panels that are whole aluminum made and steel core panels were belong to panel cores with triangular profiles and the least deflection were for rectangular shaped profiles. In panels that only have steel sheets, unlike the other panels, the most deflection was for rectangular profiles and the least deflection was for triangular ones.