The need for more high-rise buildings that have complex reactions to earthquakes makes controlling soil-structure interactions particularly important. Also, the architectural and aerodynamic requirements of high-rise buildings that lead to post-deposition necessitate further studies is inevitable on the effects of post-depositional and soil-structure interactions. In this study, a three-dimensional, 25 floors reinforced concrete frame with a particular moment frame structural system along the X  and Y  line in a very dangerous area (a= 0.3g) with two models with the height of floors (3.2-4.2) has regular (1-12) and with post-depositional (13-25) floors on the soil (I, II, and III ) is assumed without soil-structure interaction. The purpose of the present study was to determine the maximum horizontal lateral displacement (absolute, drift) floors, base shear and invert anchor frames. To model the sub-foundation soil from Themickwolf's cone model, determination of coefficient of dynamic stiffness of spring and damping coefficient using discrete model based cone model in half homogeneous space for the analysis of soil-structure interaction from the subsurface method. For seismic load analysis, the nonlinear time history dynamic analysis method by direct integration method under seven accelerometers was used and geometric modelling was performed on all sap2000-v18 software. The result shows that with change in soil type (II  to I , III  to I , and III  to II ) without and with soil-structure interaction, the trend of the maximum lateral displacement (absolute, drift) in two model (1 and 2) of storeys (1-25) along (X  and Y ) increasing, maximum percent increase in lateral displacement (absolute-drift) from the floors (13-25) to the floors (1-12) respectively, lateral displacement (decrease-increase) and soil (II  to I ) without and with soil-structure interaction from the floors (1–25) due to stay periodic the soil (I  and II ) does not change. Also, the maximum base shear is reduced of model 2 to 1 the soils (I, II, and III )  without and with interaction along (X  and Y ), and the maximum overturn anchor is increased.